Found 242 articles for: "basal cell carcinoma"
Resident Spotlight. Orlando Dermatology Aesthetic & Clinical Conference (ODAC): Fourth Annual ARTE Poster Competition
August 2013 | Volume 12 | Issue 8 | Features | 949 | Copyright © August 2013
Efficacy, Tolerability, and Pharmacodynamics of Apremilast in Recalcitrant Plaque Psoriasis: A Phase II Open-Label Study
August 2013 | Volume 12 | Issue 8 | Original Article | 888 | Copyright © August 2013
BACKGROUND: Apremilast, a small molecule specific inhibitor of phosphodiesterase 4, works intracellularly to modulate pro-inflammatory and anti-inflammatory mediators. This phase II, multicenter, open...
Read MoreCurrent Methods for Photodynamic Therapy in the US: Comparison of MAL/PDT and ALA/PDT
August 2013 | Volume 12 | Issue 8 | Original Article | 925 | Copyright © August 2013
There is some debate regarding the rate of progression of actinic keratosis (AK) into squamous cell carcinoma (SCC).1-4 However, it is clear that treatment for AK lesions is warranted. Results from nu...
Read MorePipeline Previews
July 2013 | Volume 12 | Issue 7 | Features | 833 | Copyright © July 2013
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from th...
Read MoreA Review and Update on Melanocyte Stimulating Hormone Therapy: Afamelanotide
July 2013 | Volume 12 | Issue 7 | Original Article | 775 | Copyright © July 2013
Afamelanotide ([Nle4-D-Phe7]-alpha-MSH) is an analog of alpha-melanocyte stimulating hormone given as a subcutaneous injection. Afamelanotide is currently undergoing phase II and III trials in Europe ...
Read MoreClinical Trial Review
June 2013 | Volume 12 | Issue 6 | Features | 720 | Copyright © June 2013
Clinical Trial Review is a JDD department designed to provide physicians with information on drugs and devices undergoing clinical testing. It is our goal to inform the reader of the status of select...
Read MoreSign and Pseudo-Sign of Leser-Trélat: Case Reports and a Review of the Literature
May 2013 | Volume 12 | Issue 5 | Original Article | 79 | Copyright © May 2013
BACKGROUND: Leser-Trélat is distinguished by a rare paraneoplastic sign that is characterized by the sudden eruption of multiple seborrheic keratoses (SKs), associated with underlying internal ma...
Read MoreNonmelanoma Skin Cancer in Young Women
May 2013 | Volume 12 | Issue 5 | Original Article | 568 | Copyright © May 2013
The increasing incidence of nonmelanoma skin cancer in young women is a growing public health concern. Varying environmental and lifestyle exposures in this specific population highlight the need for ...
Read MoreInflammatory Mediators are Inhibited by a Taurine Metabolite in CpG Oligodeoxynucleotide and IFN-r Activated Macrophage Cell Line
May 2013 | Volume 12 | Issue 5 | Original Article | 551 | Copyright © May 2013
Taurine plays an important role in brain and retinal development, and has an antiinflammatory and antioxidant function. Taurine chloramine (Tau-Cl) is produced in polymorphonuclear leukocytes via the ...
Read MoreNontraditional Management of Basal Cell Carcinoma
May 2013 | Volume 12 | Issue 5 | Original Article | 525 | Copyright © May 2013
This review discusses nontraditional modalities available for the treatment of basal cell carcinoma along with the existing evidence to support their respective uses in varying clinical situations. By...
Read MoreTargeting the Hedgehog Pathway to Treat Basal Cell Carcinoma
May 2013 | Volume 12 | Issue 5 | Original Article | 519 | Copyright © May 2013
The discovery of mutations that activate hedgehog (Hh) signaling in basal cell carcinoma (BCC) and other cancers has spurred the development of small molecule inhibitors that target the Hh pathway. Hi...
Read MoreCosmeceuticals for Recurrence Prevention After Prior Skin Cancer: An Overview
May 2013 | Volume 12 | Issue 5 | Original Article | 516 | Copyright © May 2013
INTRODUCTION: Skin cancer is the most common form of cancer in the United States. According to the World Health Organization, the incidence of both nonmelanoma and melanoma skin cancers has increased ...
Read MoreVitamin A and Its Derivatives in Experimental Photocarcinogenesis: Preventive Effects and Relevance to Humans
April 2013 | Volume 12 | Issue 4 | Original Article | 458 | Copyright © April 2013
The 1925 classical observation that vitamin A deficiency leads to squamous metaplasia and epithelial keratinization, coupled with the later finding that excess vitamin A inhibits keratinization of chi...
Read MoreKeloids: An Update on Medical and Surgical Treatments
April 2013 | Volume 12 | Issue 4 | Original Article | 403 | Copyright © April 2013
Keloids are the result of an overgrowth of dense fibrous tissue that usually develops after healing of a skin injury. Despite their common occurrence, keloids remain one of the most challenging dermat...
Read MoreA Short Educational Intervention Measurably Benefits Keloid-Prone Individuals' Knowledge of Prevention and Treatment
April 2013 | Volume 12 | Issue 4 | Original Article | 397 | Copyright © April 2013
BACKGROUND: The Internet is a commonly utilized health information resource that provides access to information of varying quality.
OBJECTIVE: We sought to evaluate the use of the Internet as a ...
Read MoreAssessment of a Superficial Chemical Peel Combined With a Multimodal, Hydroquinone-Free Skin Brightener Using In Vivo Reflectance Confocal Microscopy
March 2013 | Volume 12 | Issue 3 | Supplement Individual Articles | 38 | Copyright © March 2013
The combination of in-office procedures such as chemical peels with topical maintenance therapies has been shown to provide greater efficacy than either treatment by itself in the management of melasm...
Read MoreAssessment of Syndecan-1 (CD138) and Ki-67 Expression for Differentiating Keratoacanthoma and Squamous Cell Carcinoma
March 2013 | Volume 12 | Issue 3 | Original Article | 53 | Copyright © March 2013
BACKGROUND: There is a major controversy over the natural behavior of keratoacanthoma (KA). KAs have been described as benign lesions, but also as variants of squamous cell carcinoma (SCC). Microscopi...
Read MoreTopical Formulation Engendered Alteration in p53 and Cyclobutane Pyrimidine Dimer Expression in Chronic Photodamaged Patients
March 2013 | Volume 12 | Issue 3 | Original Article | 336 | Copyright © March 2013
While the clinical attributes of photoaging are well characterized in the literature, the pathogenic mechanisms that underlie these changes are incompletely elucidated. At the molecular level, p53 tum...
Read MoreSkin Cancer in Skin of Color: An Update on Current Facts, Trends, and Misconceptions
February 2013 | Volume 12 | Issue 2 | Original Article | 194 | Copyright © February 2013
For many fair-skinned individuals around the world, skin cancer is the leading malignancy. Although skin cancer comprises only 1% to 2% of all malignancies in those with darker complexions, the mortal...
Read MoreThe "Jigsaw Puzzle" Advancement Flap for Reconstruction of a Retroauricular Surgical Defect
January 2013 | Volume 12 | Issue 1 | Case Reports | 115 | Copyright © January 2013
Repairing retroauricular defects is quite challenging. Although direct observation of the repaired defect is not possible, choosing the wrong reconstruction might result in serious deformity of the au...
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